Table 4.
Pre-review mean antidepressant prescribed daily dose and defined daily dose equivalent
| ADMs prescribed, n (%) (N = 2883) | Mean dose (SD) (mg) | Range, mg | Median, mg | Mean PDD as DDD | Mean PDD as DDD (SD) from literature4,14–16 | |
|---|---|---|---|---|---|---|
| Fluoxetine | 773 (26.8) | 28.7 (13.0) | 10–60 | 20 | 1.43 (0.65) | 1.05 [Poluzzi et al 20044] 1.07 [Donoghue et al 199614] 1.08 [Truter & Kotze16] |
| Citalopram | 744 (25.8) | 28.2 (13.8) | 4.3–60 | 20 | 1.41 (0.69) | 1.17 [McManus et al 200315] 1.3 [Poluzzi et al 20044] 1.2 [Truter & Kotze16] |
| Paroxetine | 250 (8.7) | 26.2 (10.5) | 5–60 | 20 | 1.31 (0.52) | 0.90 [Poluzzi et al 20044] 1.13 [Donoghue et al 199614] 1.15 [McManus et al 200315] 1.05 [Truter & Kotze16] |
| Venlafaxine | 210 (7.3) | 139.6 (72.2) | 18.75–375 | 150 | 1.40 (0.72) | 1.22 [McManus et al 200315] |
| Trazodone | 194 (6.7) | 171.3 (105.0) | 50–600 | 150 | 0.57 (0.35) | 0.30 [Poluzzi et al 20044] |
| Sertraline | 178 (6.2) | 94.4 (41.3) | 25–200 | 100 | 1.89 (0.83) | 0.90 [Poluzzi et al 20044] 1.60 [Donoghue et al 199614] 1.45 [McManus et al 200315] |
| Mirtazapine | 175 (6.1) | 35.5 (10.5) | 15–60 | 30 | 1.18 (0.35) | 1.25 [Poluzzi et al 20044] |
| Dosulepin | 145 (5.0) | 103.3 (49.0) | 25–225 | 75 | 0.69 (0.33) | 0.51 [Donoghue et al 199614] 0.55 [McManus et al 200315] |
| Escitalopram | 70 (2.4) | 15.4 (6.5) | 5–40 | 20 | 1.54 (0.65) | |
| Lofepramine | 61 (2.1) | 141.2 (53.9) | 70–280 | 140 | 1.34 (0.51) | 1.28 [Donoghue et al 199614] |
| Duloxetine | 33 (1.1) | 65.6 (29.0) | 30–120 | 60 | 1.09 (0.48) | |
| Other | 50 (1.7) | |||||
ADMs = antidepressant medicines. DDD = defined daily doses. PDD = prescribed daily dose. SD = standard deviation.