Figure 6. Englerin A sensitivity does not correlate with any known mutations in kidney cancer cell lines.

Renal cell carcinoma cell lines from the NCI-60 cell panel and a glioblastoma cell line (SF-295) were arranged by decreasing sensitivity to the englerin A natural product as determined by Akee and colleagues. [11] The known mutation status in the cell lines as characterized by Ikediobi and colleagues [44] and as obtained from the Wellcome Trust Sanger Institute Cancer Genome Project web site (http://www.sanger.ac.uk/genetics/CGP) are shown in red (mutated) or green (wild-type).