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Potential HA signalling pathway mediated by CD44 and TGF-β1 receptors. Microarray and PCR analysis showed that several TGF-β1 intermediates, including the transcription factors c-Myc and E2F4, are upregulated following HA treatment. HA-induced signalling may be mediated by HA binding to CD44, which is known to bind to and activate the TGF-β1 receptor. (Online version in colour.)
