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. 2012 Aug 22;9(77):3165–3183. doi: 10.1098/rsif.2012.0417

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Figure 1. — Loss of single-cell resolution is endemic to tissue-level analyses. Loss of resolution can be due to: (a) signal dilution, in which a lowly expressed biomolecule (red triangles) fails to be detected owing to the predomination of other species (white squares) in the aggregate sample; or (b) signal averaging, in which the biologically relevant ratios of biomolecular species are inaccurately represented in the aggregate sample (total number of a particular mRNA divided by the number of cells). The nucleus of the cell is depicted in the green oval situated in each cell.