Table 3.
Differences (95% CIs) in mean levels of BMI and total cholesterol at age 44–45 years by gestational age after adjustment for prenatal factors and potential mediators in women
| Risk factors for CVD/Gestational age (weeks) | Model 1 | Model 2 | Model 3 |
|---|---|---|---|
| BMI (kg/m2) | N = 3317 | ||
| <37 | 1.50 (0.36, 2.63) | 1.05 (−0.08, 2.17) | 0.89 (−0.23, 2.00) |
| 37 | −0.37 (−1.40, 0.66) | −0.55 (−1.57, 0.47) | −0.59 (−1.60, 0.42) |
| 38 | 0.14 (−0.59, 0.87) | −0.02 (−0.74, 0.70) | 0.03 (−0.68, 0.74) |
| 39 | 0.03 (−0.50, 0.56) | 0.07 (−0.45, 0.60) | 0.04 (−0.47, 0.56) |
| 40 | 0 | 0 | 0 |
| 41 | 0.59 (0.05, 1.14) | 0.53 (−0.01, 1.06) | 0.49 (−0.04, 1.02) |
| >41 | 0.84 (0.20, 1.48) | 0.72 (0.08, 1.35) | 0.61 (−0.01, 1.24) |
| P-value* | 0.01 (0.01) | 0.05 (0.04) | 0.09 (0.08) |
| Total cholesterol (mmol/l) | N = 2757 | ||
| Per 1 week increase | −0.02 (−0.04, 0.001) | −0.02 (−0.04, 0.002) | −0.02 (−0.05, −0.001) |
| P-value | 0.06 | 0.07 | 0.04 |
*P-values from models including gestational age as a continuous term (P-value for quadratic term shown in parentheses if there is evidence of deviation from linearity).
Model 1: Adjusted for birthweight standardized by gestational age and sex and, in model of total cholesterol also for current BMI.
Model 2: Model 1 plus prenatal factors (maternal age, maternal smoking, pre-eclampsia, father's occupational class).
Model 3: Model 2 plus potential mediators (educational level, own occupational class, smoking and alcohol consumption in adulthood).