Table.

	Gene	Genetic Lesion	Expression/ Activity Level	Cancer Association	Ref
Ribosomopathies
X-DC	DKC1	Mutation/ Deletion	Decrease	Increased incidence of hematological and solid tumors	[1]
DBA	RPS 7,15,17,19, 24,27A RPL 5,11,35A,36	Mutation/ Deletion	Decrease	Increased incidence of hematological and solid tumors	[60–65]
5q-syndrome	RPS14	Deletion	Decrease	Increased incidence of hematological tumors	[66]
SDS	SBDS	Mutation	Decrease	Increased incidence of hematological tumors	[67,68]
CHH	RMRP	Mutation	Decrease	Increased incidence of hematological and solid tumors	[69]
Translation Initiation Factors	eIF2α	ND	Increase	In hematological and solid tumors	[40,70]
	eIF3a	ND	Increase	In solid tumors	[71,72]
	eIF3c	ND	Increase	In solid tumors	[73]
	eIF3e	ND	Increase	In solid tumors	[74]
	eIF3f	ND	Decrease	In solid tumors	[75]
	eIF3h	Amplification	Increase	In solid tumors	[76]
	eIF3i	ND	Increase	In solid tumors	[77,78]
	eIF4A	ND	Increase	In solid tumors	[79,80]
	eIF4E	ND	Increase	In hematological and solid tumors	[35]
	eIF4G	Amplification	Increase	In solid tumors	[81,82]
	eIF5A	ND	Increase	In hematological tumors	[83]
	eIF5A2	Amplification	Increase	In solid tumors	[84]
	eIF6	ND	Increase	In hematologic and solid tumors	[85,86]
Translation Elongation Factors	eEF2	ND	Increase	In solid tumors	[87]
	eEF1A2	Amplification	Increase	In solid tumors	[88,89]
IRES Trans-Acting Factors	hnRNP A1	ND	Increase	In solid tumors	[90]
	hnRNP E1	ND	Decrease	In solid tumors	[91,92]
	hnRNP E2	ND	Decrease	In solid tumors	[93]
	La	ND	Increase	In solid tumors	[94]
	PTB	ND	Increase	In solid tumors	[95]
	YB1	ND	Increase	Correlates with higher grade cancers	[96]
Ribosome Biogenesis Factors	Ubf1	ND	Increase	In solid tumors	[97]
	Bop1	Amplification	Increase	In solid tumors	[98]
	Npm	Mutation	Decrease	Associated with hematological tumors	[99]

X-DC: x-linked dyskeratosis congenita; DBA: Diamond Blackfan anemia; SDS: Shwachman-Diamond syndrome; CHH: cartilage hair hypoplasia; RPS: ribosomal protein small subunit; RPL: ribosomal protein large subunit