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Mean unscaled concentration-versus-time profiles in mouse models of melanoma and patients with cutaneous melanoma. (A): Total Pt in plasma. (B): UF Pt in plasma.
Abbreviations: GEMM, genetically engineered mouse model; OST, orthotopic syngeneic transplant; Pt, platinum; TRIA, tyrosinase-H-RasG12V INK4A−/−/ARF−/−; UF, ultrafiltrate.
