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Mean and individual concentration-versus-time profiles of plasma Pt and tumor ECF Pt. (A): Patients with cutaneous melanoma. (B): TRIA GEMMs. (C): TRIA OSTs. (D): B16 OSTs. (E): A375 xenograft tumors.
Abbreviations: ECF, extracellular fluid; GEMM, genetically engineered mouse model; OST, orthotopic syngeneic transplant; Pt, platinum; TRIA, tyrosinase-H-RasG12V INK4A−/−/ARF−/−; UF, ultrafiltrate.
