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Mean allometrically scaled concentration-versus-time profiles in mouse models of melanoma and patients with cutaneous melanoma. (A): Total plasma Pt. (B): Plasma ultrafiltrate Pt. (C): Tumor ECF Pt.
Abbreviations: ECF, extracellular fluid; GEMM, genetically engineered mouse model; OST, orthotopic syngeneic transplant; Pt, platinum; TRIA, tyrosinase-H-RasG12V INK4A−/−/ARF−/−.
