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. 2012 Sep 19;17(10):1303–1316. doi: 10.1634/theoncologist.2012-0274

Table 1.

PK parameters of Pt after intravenous administration of carboplatin in different models of melanoma

graphic file with name onc01012-1174-t01.jpg

aStatistically different from human PKs.

bMean plasma and plasma UF PK parameters were calculated via the destructive sampling method and thus there is only one value per group. For tumor ECF, mean and SD are reported.

cBecause both the TRIA GEMM and TRIA OST model were in male FVB mice as the backbone, plasma and plasma UF PK parameters are the same. AUC0-last for plasma is from 0–24 hours in the B16 OST model and patients and from 0–6 hours in the GEMM and TRIA OST model. AUC0-last for tumor ECF is from 0–4 hours in all models.

Abbreviations: AUC, area under the concentration versus time curve; Cmax, maximum concentration; ECF, extracellular fluid; GEMM, genetically engineered mouse model; MRT, mean residence time; OST, orthotopic syngeneic transplant; PK, phamacokinetics; Pt, platinum; SD, standard deviation; TRIA, tyrosinase-H-RasG12V INK4A−/−/ARF−/−; UF, ultrafiltrate.