Table 1.

Impact of ectonucleotidases on solid organ transplantation and allo-HCT.

Model	Ectonucleotidase	Biological impact	Reference
Cardiac xenograft transplantation	CD39	Attenuated survival of CD39-deficient xenografts in a model of delayed xenograft rejection with enhanced parenchymal injury, infarction and platelet aggregation	[4]
Cardiac xenograft transplantation	CD39	Increased intravascular platelet sequestration and focal myocardial infarction in complement-depleted, presensitized Cd39−/− recipients	[42]
Cardiac xenograft transplantation	CD39	Adenovirus-mediated CD39 overexpression leads to significantly prolonged xenograft survival with reduced vascular thrombosis	[43]
Cardiac allograft/discordant xenograft transplantation	CD39	Attenuated platelet deposition with preserved cardiac architecture and improved graft survival in mice overexpressing hCD39	[44]
Murine allogeneic skin transplantation with adoptive Treg transfer	CD39	CD39-deficient Tregs fail to suppress skin allograft rejection	[45]
Murine syngeneic kidney transplantation	CD39	Reduced acute tubular necrosis and apoptosis, improved graft function and prolonged survival in hCD39 overexpressing isografts	[46]
Murine allogeneic cardiac transplantation	CD73	Reduced graft survival and more severe cardiac allograft vasculopathy when donor or recipient is CD73-deficient	[47]
Murine allogeneic tracheal transplantation	CD73	Cd73−/− recipients show significantly reduced allograft survival with increased airway luminal obliteration and T-cell infiltration	[48]
Murine allogeneic hematopoietic cell transplantation	CD73	CD73 deficiency of donor or recipient enhances acute GvHD severity and pharmacologic CD73 blockade improves GvL activity	[49]
Murine allogeneic hematopoietic cell transplantation	Apyrase treatment	Reduced acute GvHD severity, T cell expansion, IFN-γ production and increased Treg numbers	[50]
Cardiac xenograft transplantation	Apyrase treatment	Attenuated intragraft platelet aggregation and prolonged survival time	[51]
Rat syngeneic lung transplantation	Apyrase treatment	Protection against pulmonary edema, improved oxygenation, attenuated neutrophil activity, apoptosis, and inflammatory cytokine production	[52]