Fig. 12.

Stress-based overload. A constant uniaxial tissue stress σ is applied to two tissue samples such that the collagen fibrils are stretched beyond their homeostatic stretch state λ^hom. The tissues can either grow in thickness direction through increasing the collagen fibril density η^col (red line) or remodel through the adaptation of the residual stretch λ_R (dashed blue line) to overcome the overload and to regain homeostasis at the collagen fibril level. From left to right, shown is the qualitative evolution of the collagen fibril stretch λ^fib, the residual stretch λ_R and the collagen fibril density η^col. The results are based on the G&R algorithm proposed in Grytz et al. (2011b). (For interpretation of the references to color in this figure legend, the reader is referred to the web version of the article.)