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. Author manuscript; available in PMC: 2013 Oct 1.
Published in final edited form as: Arterioscler Thromb Vasc Biol. 2012 Aug 16;32(10):2444–2451. doi: 10.1161/ATVBAHA.112.252205

Figure 1. ADAM15 deficiency reduces atherosclerosis and alters macrophage, SMC and collagen deposition in atherosclerotic lesions of Apoe−/− mice.

Figure 1

After consuming an atherogenic diet for 12 weeks, aortas were dissected from Apoe−/−Adam15−/− mice (n=10) and their Apoe−/−Adam15+/+ littermates (n=10). A, en face staining of lesion with oil red O in thoracic-abdominal aorta (TA), *p<0.05 vs. Apoe−/−Adam15+/+ mice. B, C, longitudinal sections of aortic arches (B) and cross-sections of aortic sinuses (C) stained with oil red O for intimal area and lipid deposition. L, lumen; A, adventitia. D–F, cryosections of aortic were immunostained for macrophages (Mφ, D) and smooth muscle cells (SMC, E) with anti-Mac-3 and anti-α-actin, respectively. Collagen (F) was stained with picrosirius red. *p<0.05, **p<0.01 vs. Apoe−/− Adam15+/+ mice. L, lumen; A, adventitia. Shown right are representative photographs.