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. 2012 Oct 20;18:2578–2585.

Table 1. Summary of SNPs examined and reasons for selecting these candidates.

Gene # of SNPs examined Function Reasons for selecting gene
PLA2G12A
1
Participates in helper T cell Immune response [16]
Association with AMD [33]
IL-23R
11
Regulates IL-1A expression [35]
Regulator of IL-17 expression [35]
STAT3
1
Transcriptional factor in IL-23/IL-17 pathway [35]
Regulator of IL-17 Expression [35]
VEGFA
4
Promotes Neovascularization [36]
Higher secretion in AMD patients [37]
KDR
1
Receptor for VEGFA [38]
Differences in receptor expression or function may affect VEGF binding [39]
HIF-1A 3 Oxygen dependent transcriptional activator [40] Regulates VEGF expression [40]