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. 2012 Oct 26;7(10):e48150. doi: 10.1371/journal.pone.0048150

Figure 6. hDDAH1 overexpression is able to attenuate the hypertensive injury in the kidney.

Figure 6

(A) Renal profibrotic marker: determination of murine plasminogen activator inhibitor-1 (PAI-1) gene expression in kidney tissue. Renal proinflammatory markers: determination of monocyte chemoattractant protein-1 (MCP-1; B) and vascular cell adhesion molecule-1 (VCAM-1; C) gene expression in kidney tissue. hDDAH1 = human dimethylarginine dimethylaminohydrolase1, WT = wild-type. PAI-1: WT normotensive: N = 11, hDDAH1 normotensive: N = 9, WT hypertensive: N = 10, hDDAH1 hypertensive: N = 7. MCP-1: WT normotensive: N = 10, hDDAH1 normotensive: N = 9, WT hypertensive: N = 10, hDDAH1 hypertensive: N = 9. VCAM-1: WT normotensive: N = 7, hDDAH1 normotensive: N = 7, WT hypertensive: N = 7, hDDAH1 hypertensive: N = 6.