Figure 5. RBPcKO homozygous female mice exhibited atypical olfactory preferences.

(A) The three groups showed similar frequencies of total hole pokes, thus establishing that there were no differences in this type of exploratory activity which would affect subsequent olfactory preference behaviors. (B) An ANOVA conducted on the poke frequencies into empty and odorant-containing corner holes revealed a significant genotype by sex by hole interaction (p = 0.006), and subsequent comparisons showed that the female RBPcKO homo mice had a significant preference (beyond Bonferroni correction) for the empty versus the odorant-containing holes (*p = 0.008), while other groups, such as the WT females, preferred (†p = 0.028), or at least tended to prefer, the odorant-containing holes. (C) Planned comparisons revealed that only WT control mice showed a significant preference for the familiar (bedding) odor versus the novel (coconut) odor (*p = 0.0025), although the RBPcKO groups showed a tendency toward the same preference.