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. Author manuscript; available in PMC: 2013 Oct 4.
Published in final edited form as: Oncogene. 2012 Jul 23;32(14):1772–1783. doi: 10.1038/onc.2012.205

Figure 9.

Figure 9

Scheme for CD151 contributions to chemical carcinogenesis in skin. Stimulation of epidermoid cells by EGF and TPA, through EGFR and PKCα, are enhanced when CD151 is present. Signaling is weakened when CD151 is absent, as evidenced by increased potency of agents inhibiting EGFR, PKCα, JAK2/TYK2, and STAT3. CD151 recruits PKC into proximity with β4 integrin. The β4 cytoplasmic tail has previously been linked to JAK2-STAT3 activation (24). It remains to be determined the extent to which CD151- and PKCα-dependent β4 S1424 phosphorylation directly contributes to STAT3 activation and skin oncogenesis. Results obtained here support previously demonstrated links of STAT3 to skin tumor initiation, promotion, and progression (10; 11).