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Neutrophil reverse migration. Following tissue injury, neutrophils are rapidly attracted to the injury site by a tissue gradient of hydrogen peroxide (Niethammer et al., 2009). The majority of neutrophils migrate back to the vasculature (reverse migration) during resolution of inflammation (Mathias et al., 2006; Yoo and Huttenlocher, 2011). The underlying mechanisms that regulate neutrophil reverse migration are not known.
