Fig. 7.

Model depicting the roles of opposing kinesin and dynein motors in the nuclear dynamics in developing myotubes. Motors are bound to the nucleus through nesprins or other links. The number and distribution of opposing motors on a nucleus and the polarity of the local microtubule network determine the direction and speed of rotation and translocation. Depletion of either dynein or KIF5B from myotubes causes abnormal aggregation and inappropriate dispersal of nuclei along the length of the myotube.