Figure 6. Cisplatin severely decreases hearing but does not disproportionally affect dCKO mice.

Ototoxic drugs, such as cisplatin are well-known to cause hearing loss, shown by large ABR threshold shifts. Upon administration of cisplatin to WT mice, a large threshold shift was seen compared to untreated mice (compare vertical red line to black circle). A nearly equal threshold shift was observed when comparing treated and untreated dCKO mice (compare green “x” with blue triangle) suggesting that while both groups of mice were negatively affected by the cisplatin treatment, the hearing loss was comparable between the two groups.