Table 3.
Correlation between the expression of FOXP3 mRNA in blood mononuclear cells (MNC), the percentage CD4+ CD25hi T cell subsets and expression of mRNA encoding the E3 ubiquitin ligases CBLB and ITCH. Expression was studied in healthy controls, untreated patients with multiple sclerosis (MS) and MS patients treated with interferon (IFN)-β. Data are Spearman's rank correlation coefficients with P-values for correlations with FOXP3 expression
| Healthy controls | Untreated MS | IFN-β treated MS | |
|---|---|---|---|
| CD4+ CD25high T cells (% of CD4+ T cells) | n.s. | n.s. | n.s. |
| CD4+ CD25high T cells (% of blood MNCs) | n.s. | n.s. | n.s. |
| CD4+ CD25high T cells with cell surface CTLA-4 (%) | n.s. | 0·66, P = 0·008 | n.s. |
| CBLB | n.s. | 0·80, P < 0·001 | 0·83, P < 0·001 |
| ITCH | n.s. | n.s. | 0·71, P = 0·003 |
| TBX21 | n.s. | n.s. | n.s. |
| IFNG | n.s. | n.s. | 0·66, P = 0·008 |
| TNF | n.s. | n.s. | n.s. |
| GATA3 | 0·78, P = 0·001 | 0·88, P < 0·001 | 0·86, P < 0·001 |
| IL4 | n.s. | n.s. | 0·83, P < 0·001 |
| IL13 | n.s. | n.s. | n.s. |
| TGFB1 | n.s. | n.s. | 0·88, P < 0·001 |
| IL10 | n.s. | n.s. | n.s. |
CTLA-4: cytotoxic T lymphocyte antigen 4; n.s.: not significant.