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Free energy of melting native, mutant1 and mutant2 hairpins calculated using the combination of free energy changes from optical melting experiments and nearest neighbor parameters (from the NNDB).
| Native | Mutant1 | Mutant2 | |
|---|---|---|---|
| ΔGNN (kcal/mol) | −3.5 ± 0.2 | −1.3 ± 0.3 | 0.8 ± 0.3 |
Errors are calculated from the errors given with the parameters in NNDB and by taking into account that the changes in enthalpy and entropy are correlated.45
