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Free energy change in kcal/mol for transition from native to mutant1, native to mutant2 and mutant1 to mutant2 hairpins calculated using a thermodynamic cycle.
| Native ← Mutant1 | Native ← Mutant2 | Mutant1 ← Mutant2 | |
|---|---|---|---|
| Simulation | −4.0 ± 2.2 | −5.5 ± 1.7 | −1.5 ± 2.7 |
| Nearest Neighbor | −2.2 ± 0.2 | −4.3 ± 0.2 | −2.1 ± 0.2 |
|
| |||
| Difference | 1.8 | 1.2 | −0.6 |
