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. Author manuscript; available in PMC: 2013 Nov 4.
Published in final edited form as: Obesity (Silver Spring). 2013 Apr;21(4):835–846. doi: 10.1002/oby.20268

Table 2.

Meta-analysis of linear regression of putative obesity-related SNPs and per-allele difference in mean BMI (kg/m2), stratified by racial/ethnic group

Gene SNP Location CA European Americans; mean BMI = 27.48 Hispanics; mean BMI = 28.86 African Americans; mean BMI = 29.80
Effect Size (95% CI)* p-value N AF power Effect Size (95% CI)* p-value N AF power Effect Size (95% CI)* p-value N AF power
NEGR1 rs2815752 1p31.1 T 0.14 (0.03 – 0.22) 9.16E-03 28261 0.63 0.55 0.00 (−0.32 – 0.32) 0.99 2891 0.71 0.09 0.03 (−0.12 – 0.18) 0.7 10576 0.54 0.2
TMEM18 rs6548238 2p25.3 C 0.28 (0.17 – 0.39) 8.59E-08 37061 0.83 0.99 0.06 (−0.23 – 0.35) 0.7 6398 0.87 0.4 0.39 (0.18 – 0.60) 2.41E-04 14492 0.88 0.59
GNPDA2 rs10938397 4p12 G 0.08 (0.00 – 0.19) 0.04 31346 0.43 0.99 0.17 (−0.03 – 0.38) 0.11 6369 0.38 0.44 0.27 (0.09 – 0.42) 1.49E-03 14383 0.24 0.56
MTCH2 rs10838738 11p11.2 G 0.14 (0.06 – 0.22) 1.01E-03 34679 0.35 0.36 0.23 (0.03 – 0.41) 0.03 6406 0.37 0.1 −0.18 (−0.41 – 0.06) 0.15 13653 0.1 0.08
SH2B1 rs7498665 16p11.2 G 0.06 (−0.03 – 0.17) 0.22 31383 0.38 0.91 0.00 (−0.20 – 0.20) a 0.98 6391 0.45 0.31 0.15 (−0.03 – 0.30) 0.09 13642 0.27 0.39
FTO rs1121980 16q12.12 A 0.42 (0.28 – 0.53) 7.60E-12 21645 0.43 0.99 −0.09 (−1.49 – 1.42) 0.91 426 0.37 0.31 0.12 (−0.15 – 0.36) 0.38 4005 0.47 0.98
FTO rs3751812 16q12.12 T 0.39 (0.28 – 0.50) 4.21E-14 25776 0.52 0.99 0.17 (−0.34 – 0.67) 0.53 1911 0.275 0.41 0.12 (−0.33 – 0.60) 0.6 4549 0.118 0.4
FTO rs8050136 16q12.12 A 0.39 (0.28 – 0.47) 2.78E-14 26544 0.41 0.99 0.38 (0.09 – 0.67) 9.91E-03 3674 0.29 0.68 0.18 (−0.01 – 0.33) 0.06 9435 0.43 0.96
FTO rs9930506 16q12.12 G 0.39 (0.28 – 0.53) 3.27E-11 21998 0.44 0.99 0.29 (−0.20 – 0.82) 0.24 1912 0.32 0.84 0.00 (−0.27 – 0.27) 0.97 7065 0.21 0.99
FTO rs9939609 16q12.12 A 0.36 (0.28 – 0.47) 4.61E-15 28286 0.4 0.99 −0.37 (−1.68 – 1.00) 0.58 449 0.33 0.13 0.03 (−0.15 – 0.24) 0.7 6492 0.47 0.82
MC4R rs12970134 18q22 A 0.22 (0.08 – 0.33) 1.31E-03 21987 0.26 0.92 −0.74 (−2.06 – 0.67) 0.3 448 0.17 0.07 0.18 (−0.21 – 0.54) 0.38 4046 0.13 0.15
MC4R rs17782313 18q22 C 0.06 (0.00 – 0.14) 0.08 35398 0.22 0.98 0.12 (−0.17 – 0.38) 0.41 6388 0.13 0.26 0.18 (0.01 – 0.33) 0.04 13698 0.29 0.63
KCTD15 rs11084753 19q13.11 G 0.03 (−0.05 – 0.11) 0.61 29411 0.67 0.24 0.20 (−0.09 – 0.52) 0.18 2891 0.65 0.07 0.03 (−0.12 – 0.18) 0.72 10795 0.64 0.1
Gene SNP Location CA East Asians; mean BMI = 24.99 Pacific Islanders; mean BMI = 28.60 American Indians; mean BMI = 31.86
Effect Size (95% CI)* p-value N AF power Effect Size (95% CI)* p-value N AF power Effect Size (95% CI)* p-value N AF power
NEGR1 rs2815752 1p31.1 T −0.17 (−0.57 – 0.25) 0.43 2041 0.91 0.08 −0.11 (−1.07 – 0.90) 0.84 392 0.81 0.05 −0.13 (−0.41 – 0.16) 0.39 6153 0.76 0.11
TMEM18 rs6548238 2p25.3 C −0.02 (−0.37 – 0.35) 0.94 2041 0.9 0.3 0.40 (−0.98 – 1.89) 0.57 392 0.92 0.07 0.06 (−0.22 – 0.35) 0.61 6186 0.78 0.43
GNPDA2 rs10938397 4p12 G −0.02 (−0.25 – 0.23) 0.92 2037 0.28 0.35 0.58 (−0.23 – 1.38) 0.16 392 0.27 0.07 0.32 (0.03 – 0.58) 0.03 6125 0.24 0.27
MTCH2 rs10838738 11p11.2 G 0.18 (−0.07 – 0.40) 0.16 2041 0.34 0.09 0.69 (−0.14 – 1.56) 0.11 392 0.34 0.05 −0.13 (−0.35 – 0.1) 0.25 6147 0.46 0.09
SH2B1 rs7498665 16p11.2 G 0.48 (0.13 – 0.81) 5.77E-03 2038 0.13 0.15 0.81 (−0.03 – 1.65) 0.06 392 0.25 0.06 0.38 (0.13 – 0.64) 2.00E-03 6149 0.59 0.23
FTO rs1121980 16q12.12 A 0.13 (−0.57 – 0.81) 0.73 672 0.21 0.7
FTO rs3751812 16q12.12 T 0.28 (−0.45 – 0.99) 0.46 701 0.18 0.3
FTO rs8050136 16q12.12 A 0.40 (0.13 – 0.66) 3.14E-03 2325 0.19 0.8 0.49 (−0.23 – 1.23) 0.18 574 0.24 0.14 0.32 (−0.01 – 0.68) 0.06 6193 0.13 0.51
FTO rs9930506 16q12.12 G 0.20 (−0.42 – 0.84) 0.53 699 0.22 0.72
FTO rs9939609 16q12.12 A 0.28 (−0.42 – 0.99) 0.45 696 0.18 0.26 0.35 (0 – 0.71) 0.05 6168 0.14 0.47
MC4R rs12970134 18q22 A 0.63 (−0.15 – 1.44) 0.11 696 0.16 0.12
MC4R rs17782313 18q22 C 0.10 (−0.17 – 0.38) 0.46 2040 0.22 0.34 −0.68 (−1.8 – 0.46) 0.24 392 0.14 0.06 0.32 (−0.19 – 0.87) 0.21 6163 0.07 0.13
KCTD15 rs11084753 19q13.11 G 0.20 (−0.05 – 0.45) 0.1 2041 0.62 0.08 −0.03 (−0.85 – 0.78) 0.93 392 0.52 0.05 0.03 (−0.22 – 0.26) 0.89 6163 0.69 0.07

CA: coded allele;

*

: Effect size is in terms of difference in mean BMI (kg/m2) associated with one copy of CA; AF: risk allele frequency; CI: confidence interval;

a

= heterogeneity I2 = 72.5, p-value = 0.03;

b

= heterogeneity I2 = 87.2, p-value = 0.005