Table 3.

Meta-analysis of logistic re=gression of putative obesity-related SNPs and obesity, stratified by racial/ethnic group

Gene	SNP	Location	CA	European Americans				Hispanics				African Americans
				Effect Size (95% CI)	p-value	N	AF	Effect Size (95% CI)	p-value	N	AF	Effect Size (95% CI)	p-value	N	AF
NEGR1	rs2815752	1p31.1	T	1.047 (0.996 – 1.100)	0.07	28261	0.63	0.997 (0.865 – 1.149)	0.97	2891	0.71	1.004 (0.942 – 1.070)	0.91	10576	0.54
TMEM18	rs6548238	2p25.3	C	1.134 (1.075 – 1.196)	3.50E-06	37061	0.83	0.959 (0.852 – 1.079)	0.49	6398	0.87	1.159 (1.067 – 1.259)	4.78E-04	14492	0.88
GNPDA2	rs10938397	4p12	G	1.027 (0.983 – 1.073)	0.23	31346	0.43	1.024 (0.942 – 1.113)	0.58	6369	0.37	1.106 (1.040 – 1.176)	0.00	14383	0.24
MTCH2	rs10838738	11p11.2	G	1.045 (1.001 – 1.091)	0.04	34679	0.35	1.109 (1.021 – 1.204)	0.01	6406	0.37	0.947 (0.868 – 1.034)	0.23	14240	0.10
SH2B1	rs7498665	16p11.2	G	1.020 (0.976 – 1.066)	0.38	31383	0.38	0.993 (0.916 – 1.077)	0.87	6391	0.44	1.032 (0.971 – 1.096)	0.31	13642	0.27
FTO	rs1121980	16q12.12	A	1.173 (1.109 – 1.239) a	1.88E-08	21645	0.43	1.260 (0.835 – 1.901)	0.27	426	0.37	1.034 (0.939 – 1.137)	0.50	4005	0.47
FTO	rs3751812	16q12.12	T	1.165 (1.107 – 1.225)	2.91E-09	25776	0.51	1.095 (0.916 – 1.309)	0.32	1911	0.28	1.056 (0.899 – 1.239)	0.51	4549	0.12
FTO	rs8050136	16q12.12	A	1.169 (1.112 – 1.228)	7.14E-10	26544	0.41	1.225 (1.085 – 1.384)	0.001	3674	0.30	1.053 (0.985 – 1.124)	0.13	9435	0.43
FTO	rs9930506	16q12.12	G	1.174 (1.111 – 1.241) b	1.11E-08	21998	0.44	1.161 (0.977 – 1.379)	0.09	1912	0.32	1.047 (0.953 – 1.150)	0.34	7065	0.21
FTO	rs9939609	16q12.12	A	1.173 (1.117 – 1.232)	1.44E-10	28286	0.41	1.051 (0.706 – 1.564)	0.81	449	0.33	1.024 (0.947 – 1.107)	0.56	6492	0.47
MC4R	rs12970134	18q22	A	1.078 (1.013 – 1.146)	0.02	21987	0.26	0.527 (0.320 – 0.866)	0.01	448	0.17	1.049 (0.911 – 1.207)	0.51	4046	0.13
MC4R	rs17782313	18q22	C	1.068 (1.019 – 1.120)	0.01	35398	0.23	1.049 (0.933 – 1.179)	0.42	6388	0.13	1.048 (0.987 – 1.112)	0.12	13698	0.29
KCTD15	rs11084753	19q13.11	G	1.010 (0.961 – 1.062)	0.69	29411	0.67	1.065 (0.931 – 1.218)	0.36	2891	0.65	1.002 (0.939 – 1.070)	0.96	10795	0.64

Gene	SNP	Location	CA	East Asians				Pacific Islanders				American Indians
				Effect Size (95% CI)	p-value	N	AF	Effect Size (95% CI)	p-value	N	AF	Effect Size (95% CI)	p-value	N	AF
NEGR1	rs2815752	1p31.1	T	0.688 (0.436 – 1.086)	0.11	2041	0.91	0.973 (0.638 – 1.484)	0.90	392	0.81	1.040 (0.910 – 1.188)	0.57	2926	0.78
TMEM18	rs6548238	2p25.3	C	0.900 (0.586 – 1.381)	0.63	2041	0.90	1.110 (0.606 – 2.033)	0.74	392	0.92	0.940 (0.822 – 1.073)	0.36	2950	0.75
GNPDA2	rs10938397	4p12	G	0.910 (0.683 – 1.214)	0.52	2037	0.28	1.512 (1.085 – 2.107)	0.01	392	0.27	0.974 (0.857 – 1.107)	0.69	2933	0.24
MTCH2	rs10838738	11p11.2	G	1.176 (0.900 – 1.536)	0.24	2041	0.34	1.161 (0.838 – 1.608)	0.37	392	0.34	1.019 (0.914 – 1.135)	0.74	2944	0.47
SH2B1	rs7498665	16p11.2	G	1.846 (1.306 – 2.609) c	5.16E-04	2038	0.13	1.362 (0.970 – 1.913)	0.07	392	0.25	0.890 (0.794 – 0.997)	0.04	2946	0.58
FTO	rs1121980	16q12.12	A	1.437 (0.836 – 2.472)	0.19	672	0.21
FTO	rs3751812	16q12.12	T	1.607 (0.944 – 2.734)	0.08	701	0.18
FTO	rs8050136	16q12.12	A	1.472 (1.109 – 1.954)	0.01	2325	0.19	1.089 (0.819 – 1.448)	0.56	574	0.24	1.029 (0.865 – 1.226)	0.74	2945	0.12
FTO	rs9930506	16q12.12	G	1.315 (0.781 – 2.216)	0.30	699	0.22
FTO	rs9939609	16q12.12	A	1.541 (0.908 – 2.614)	0.11	696	0.18					1.019 (0.855 – 1.216)	0.83	2928	0.12
MC4R	rs12970134	18q22	A	1.653 (0.881 – 3.101)	0.12	696	0.16
MC4R	rs17782313	18q22	C	1.132 (0.816 – 1.571)	0.46	2040	0.22	0.848 (0.538 – 1.337)	0.48	392	0.14	0.816 (0.624 – 1.068)	0.14	2941	0.06
KCTD15	rs11084753	19q13.11	G	1.205 (0.929 – 1.560)	0.16	2041	0.62	0.969 (0.713 – 1.318)	0.84	392	0.52	1.088 (0.968 – 1.222)	0.16	2940	0.70

CA: coded allele; AF: risk allele frequency; CI: confidence interval;

^a: heterogeneity I² = 79.7, p-value = 0.03;

^b: heterogeneity I² = 79.6, p-value = 0.03;

^c: heterogeneity I² = 82.0, p-value = 0.02