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. Author manuscript; available in PMC: 2013 Sep 1.
Published in final edited form as: Clin Cancer Res. 2012 Jul 23;18(17):4743–4752. doi: 10.1158/1078-0432.CCR-12-0707

Table 2.

Univariate and multivariate Cox proportional hazard analysis of overall survival (OS) and time-to-recurrence (TTR)

Characteristic Total n OS
TTR
Univariate
Multivariate
Univariate
Multivariate
HR (95% CI) P value HR (95% CI) P value HR (95% CI) P value HR (95% CI) P value
CIMP/MLH1 methylation 0.011 < 0.001 0.062 0.023
 CIMP−/MLH1-U 70 1.00 (Referent) 1.00 (Referent) 1.00 (Referent) 1.00 (Referent)
 CIMP+/MLH1-U 15 2.76 (1.46, 5.19) 0.002 4.73 (2.34, 9.54) < 0.001 2.26 (1.04, 4.88) 0.039 3.33 (1.39, 8.00) 0.007
 CIMP+/MLH1-M 12 0.80 (0.31, 2.07) 0.649 0.43 (0.15, 1.24) 0.117 0.21 (0.03, 1.57) 0.212 0.26 (0.03, 2.10) 0.204
 CIMP−/MLH1-M 2 0 (0, –) 0.971 0 (0, –) 0.973 0 (0, –) 0.977 0 (0, ) 0.978
Age
 <70 64 1.00 (Referent) 1.00 (Referent) 1.00 (Referent) 1.00 (Referent)
 ≥70 35 1.73 (0.99, 3.00) 0.053 2.65 (1.42, 4.92) 0.002 0.27 (0.09, 0.75) 0.013 0.47 (0.15, 1.41) 0.177
Sex
 Male 55 1.00 (Referent) 1.00 (Referent) 1.00 (Referent) 1.00 (Referent)
 Female 44 0.96 (0.55, 1.67) 0.887 1.45 (0.80, 2.65) 0.221 0.50 (0.24, 1.03) 0.061 0.90 (0.42, 1.94) 0.790
Stage
 Stage I and II 29 1.00 (Referent) 1.00 (Referent) 1.00 (Referent) 1.00 (Referent)
 Stage III and IV 70 2.72 (1.35, 5.45) 0.005 5.27 (2.25, 12.38) < 0.001 4.88 (1.71, 13.97) 0.003 4.28 (1.26, 14.50) 0.020
Differentiation
 Well/moderately 55 1.00 (Referent) 1.00 (Referent) 1.00 (Referent) 1.00 (Referent)
 Poorly 44 1.65 (0.95, 2.87) 0.078 1.42 (0.78, 2.56) 0.252 3.01 (1.48, 6.12) 0.002 2.27 (1.06,4.84) 0.034
Chemotherapy/radiotherapy
 No 38 1.00 (Referent) 1.00 (Referent) 1.00 (Referent) 1.00 (Referent)
 Yes 61 1.42 (0.79, 2.57) 0.246 1.10 (0.55, 2.20) 0.778 3.67 (1.49, 9.03) 0.005 1.87 (0.71, 4.92) 0.203
KRAS mutations
 Absent 67 1.00 (Referent) 1.00 (Referent) 1.00 (Referent) 1.00 (Referent)
 Present 32 1.09 (0.61, 1.95) 0.772 0.64 (0.34, 1.20) 0.160 1.02 (0.50, 2.09) 0.960 0.51 (0.22, 1.17) 0.111

Abbreviations: OS, overall survival; TTR, time-to-recurrence; HR, hazard ratio; CI, confidence interval; CIMP, CpG island methylator phenotype; MLH1-M, MLH1-methylated; MLH1-U, MLH1-unmethylated; MSS, microsatellite stable; MSI, microsatellite instability