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. Author manuscript; available in PMC: 2013 Sep 21.
Published in final edited form as: Org Lett. 2012 Sep 6;14(18):4730–4733. doi: 10.1021/ol301886g

Table 1.

Asymmetric Reduction of β–keto Ester

graphic file with name nihms406088u2.jpg
entry R1 R2 additive S:R
1 H t-butyl none 37:63
2 H t-butyl L-tartaric acid 15:85
3 TES t-butyl none 45:55
4 TES t-butyl L-tartaric acid 5:95
5 TES methyl L-tartaric acid 8:92
6 TES methyl D-tartaric acid 94:6
7 TBS methyl L-tartaric acid 5:95
8 TPS methyl L-tartaric acid 5:95