TABLE 2.
Characteristic | HC (n=39) | CC (n=35) | MCI (n=34) | AD (n=26) | p |
---|---|---|---|---|---|
Agea | 71.7 (5.1) | 73.9 (6.3) | 73.8 (6.3) | 76.6 (6.8) | .02h |
Educationa | 16.8 (2.6) | 16.4 (3.0) | 16.4 (3.0) | 15.4 (3.1) | ns |
Gender (M, F) | 12, 27 | 11, 24 | 16, 18 | 14, 12 | ns |
ApoE ε 4 (−,+)b | 19, 19 | 26, 9 | 15, 17 | 6, 6 | ns |
CCI c | 7.1 (5.5) | 24.4 (9.4) | 30.4 (12.0) | 37.6 (10.5) | .000i |
DRS-2d | 141.7 (1.7) | 141.2 (2.0) | 137.6 (4.1) | 123.0 (13.2) | .000j |
MMSEe | 29.0 (1.1) | 28.8 (1.3) | 26.8 (1.5) | 22.9 (4.7) | .000j |
CVLT4 | |||||
Learning | 50.8 (7.8) | 46.3 (8.6) | 34.2 (6.5) | 23.2 (7.7) | .000j |
Delay | 11.97 (2.4) | 11.1 (2.9) | 8.0 (2.9) | 4.7 (3.5) | .000j |
GDSg | 1.3 (2.0) | 4.2 (4.0) | 3.0 (2.8) | 4.4 (4.3) | .000k |
Note. Data are mean (SD) except where indicated. HC: healthy control; CC: cognitive complaints; MCI: mild cognitive impairment; AD: Alzheimer’s disease.
In years.
ApoE ε 4=genotype of apolipoprotein E, ε 4−, ε 4+. Data were unavailable for 1 HC, 2 MCI, and 14 AD participants.
Cognitive Complaint Index: percentage of all complaint items endorsed in a positive (i.e., symptomatic) direction. See text for references for component scales. Data were unavailable for 12 AD participants.
Dementia Rating Scale-2, total score (n/144). Data were unavailable for 8 AD participants.
Mini-Mental State Examination, total score (n/30). Data were unavailable for 5 AD participants.
California Verbal Learning Test II, total learning score (n/80); Long Delay Free Recall (n/16). Data were unavailable for 6 AD participants.
Adjusted Geriatric Depression Scale (n/26 noncognitive items). Data were unavailable for 4 AD participants.
AD > HC.
CC, MCI, AD > HC.
HC, CC > MCI > AD.
HC < CC, AD.