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The Role of NQO1 in potentiating the antitumor activity of benzoquinone ansamycins. Solid lines represent major pathways. Dashed lines represent minor pathways. BQA, benzoquinone ansamycin quinone; BQAH2, benzoquinone ansamycin hydroquinone; BQA-GS, benzoquinone ansamycin quinone-glutathione conjugate; Hsp90, heatshock 90 protein.
