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In vivo treatment of mice with the chemical chaperone PBA (1 g · kg−1 · day−1 for 20 days, solid symbols) reverses (A) obesity-induced glucose intolerance, (B) insulin resistance, and (C) down-regulation of IDE in the liver. *P < .05 from corresponding value in vehicle-treated mice; #P < .05 relative to corresponding STD values.
