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Anandamide inhibits insulin-induced akt-2 phosphorylation in mouse hepatocytes via ER stress-dependent activation of Phlpp1. Anandamide inhibition of insulin-induced akt-2 phosphorylation is abrogated by (A) a phosphatase inhibitory cocktail or by (B) siRNA knockdown of Phlpp1 expression. (C) Anandamide induction of Phlpp1 is inhibited by shRNA-mediated knockdown of eIF2α. (D) Anandamide activates Giα in hepatocytes. Each blot in A–D has been replicated 3 times with similar results.
