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. Author manuscript; available in PMC: 2013 Nov 1.
Published in final edited form as: Gastroenterology. 2012 Jul 27;143(5):1330–1340.e1. doi: 10.1053/j.gastro.2012.07.099

Figure 6. Reactivation of TNFRI on intestinal epithelial cells contributes to liver fibrosis.

Figure 6

(A) Reactivation of TNFRI on isolated colonic epithelial in VillinCreTNFRIflxneo/flxneo was analyzed by PCR (left panel). Tails from respective mice served as controls (right panel). (B–D) Wild type, TNFRIflxneo/flxneo and VillinCreTNFRIflxneo/flxneo mice underwent sham operation (n=3–4) or bile duct ligation (BDL; n=6 for C57BL/6, n=9–10 for TNFRIflxneo/flxneo and for VillinCreTNFRIflxneo/flxneo mice). (B and C) Collagen deposition was evaluated by Sirius red staining and quantitated by image analysis. Scale bar = 50μm. (D) Plasma endotoxin levels were measured. *p < 0.05.