Figure 1. Median plasma anaphylatoxins concentration of normal pregnant women, women with small for gestational age neonates (SGA) and women with preeclampsia with and without SGA.
A. The median plasma C5a concentration was higher in patients with preeclampsia with SGA (median: 19.7 ng/ml; range: 4.5 – 119 ng/ml) or without SGA (median: 19.7 ng/ml; range: 4.3 – 94.1 ng/ml) than normal pregnant women (median: 12.4 ng/ml; range: 1.2 – 87.1 ng/ml) or women with isolated SGA (median: 14.3 ng/ml; range: 1.1 – 30.5 ng/ml). B. In contrast, women with preeclampsia and SGA had a median plasma C4a concentration lower than normal pregnant women (preeclampsia and SGA median: 5696 ng/ml; range: 389.9 – 35690 ng/ml vs. normal pregnancy median: 10125.4 ng/ml; range: 850.7 – 32640 ng/ml; p=0.001). No differences in plasma C4a concentration were observed among other groups. C. There were no significant differences in the C3a plasma concentration among the study groups.