Table 1.
Group |
Level 1 |
Level 2 |
Level 3 |
||||||
---|---|---|---|---|---|---|---|---|---|
CDDP (mg/m2) |
35 |
50 |
65 |
||||||
Case number | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 |
Age (years) |
80 |
62 |
80 |
78 |
61 |
80 |
63 |
79 |
80 |
Gender (M, Male/F, Female) |
M |
M |
M |
M |
M |
M |
M |
F |
F |
Performance status |
1 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
HBV infection |
- |
- |
- |
- |
- |
- |
+ |
- |
- |
HCV infection |
+ |
+ |
- |
- |
- |
+ |
- |
+ |
- |
Alcohol |
- |
- |
+ |
+ |
+ |
- |
- |
- |
- |
Autoimmune hepatitis |
- |
- |
- |
- |
- |
- |
- |
- |
+ |
Child-Pugh Score |
6 |
6 |
5 |
6 |
6 |
7 |
5 |
6 |
6 |
Recurrence (Y, Yes/N, No) |
Y |
Y |
Y |
Y |
Y |
Y |
Y |
Y |
Y |
Interval to previous therapy (M) |
6 |
8 |
6 |
23 |
10 |
21 |
13 |
19 |
3 |
Previous therapy |
TACE |
TAC |
TACE |
TACE |
TAC |
TACE |
TAC |
TACE |
TACE |
History of CDDP Administration |
Y |
Y |
N |
Y |
Y |
Y |
Y |
Y |
Y |
Number of tumors |
3 |
2 |
1 |
>5 |
>5 |
4 |
4 |
>5 |
>5 |
Maximum tumor size (mm) |
15 |
15 |
14 |
20 |
10 |
34 |
24 |
10 |
30 |
Vascular invasion (Y, Yes/N, No) |
N |
N |
N |
N |
N |
N |
N |
N |
N |
Metastasis (Y, Yes/N, No) |
N |
N |
N |
N |
N |
N |
N |
N |
N |
Stage (UICC) |
II |
II |
I |
II |
II |
II |
II |
II |
II |
Tumor location (PAMLC) |
PA |
ML |
ML |
AM |
ML |
M |
P |
A |
PA |
BSA (m2) |
1.486 |
1.6 |
1.457 |
1.5 |
1.72 |
1.68 |
1.415 |
1.538 |
1.538 |
Ccr (ml/min) |
68 |
118 |
75 |
89 |
121 |
92 |
83 |
95 |
85 |
CDDP (mg/body) |
52 |
56 |
51 |
75 |
86 |
84 |
92 |
100 |
100 |
Miriplatin (mg/body) | 86 | 18 | 80 | 120 | 60 | 60 | 74 | 100 | 120 |
TACE, transarterial chemoembolization; TAC, transarterial chemotherapy. Tumour location: P, posterior segment; A, anterior segment; M, medial segment; L, lateral segment; C, caudal segment. BSA, body surface area; Ccr, creatinine clearance.