Table 2.
Haematological and nonhaematological toxicity
|
Level 1 |
Level 2 |
Level 3 |
||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
n = 3 |
n = 3 |
n = 3 |
||||||||||
| Grade | ||||||||||||
|
Hematological toxicity (grade) |
1 |
2 |
3 |
4 |
1 |
2 |
3 |
4 |
1 |
2 |
3 |
4 |
|
White blood cell decreased |
0 |
1 |
0 |
0 |
0 |
0 |
1 |
0 |
0 |
0 |
0 |
0 |
|
Neutrophil count decreased |
0 |
1 |
0 |
0 |
0 |
0 |
1 |
0 |
0 |
0 |
0 |
0 |
|
Platelet count decreased |
0 |
1 |
0 |
0 |
0 |
0 |
0 |
0 |
2 |
0 |
0 |
0 |
|
Anemia |
0 |
1 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
|
Nonhematological toxicity (grade) |
1 |
2 |
3 |
4 |
1 |
2 |
3 |
4 |
1 |
2 |
3 |
4 |
|
AST increased |
0 |
1 |
0 |
0 |
1 |
1 |
0 |
0 |
0 |
1 |
0 |
0 |
|
ALT increased |
0 |
1 |
0 |
0 |
1 |
1 |
0 |
0 |
0 |
1 |
0 |
0 |
|
Blood bilirubin increased |
0 |
0 |
0 |
0 |
1 |
0 |
0 |
0 |
1 |
0 |
0 |
0 |
|
INR increased |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
|
Hypoalbuminemia |
0 |
2 |
0 |
0 |
0 |
1 |
0 |
0 |
1 |
0 |
0 |
0 |
|
Creatinine increased |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
1 |
0 |
0 |
0 |
|
Anorexia |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
1 |
0 |
0 |
0 |
|
Nausea |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
|
Vomiting |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
|
Fever |
1 |
0 |
0 |
0 |
1 |
0 |
0 |
0 |
2 |
0 |
0 |
0 |
|
Diarrhea |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
|
Fatigue |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
1 |
0 |
0 |
0 |
|
Alopecia |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
|
Urticaria |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
| Abdominal pain | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
National Cancer Institute Common Terminology Criteria for Adverse Events version 4.0 was applied to evaluate toxicity.