Table 1.
Clinical characteristics of intracranial hemorrhage among patients of different types of hematological malignancies
| Number of patients | ||||||
|---|---|---|---|---|---|---|
| Subtype | AML (n = 43) | APL (n = 9) | ALL (n = 5) | Lymphoma (n = 7) | Myeloma (n = 8) | P value |
| Age: | 0.094 | |||||
| ≥60 years | 19 | 2 | 1 | 6 | 4 | |
| <60 years | 24 | 7 | 4 | 1 | 4 | |
| Gender: | 0.461 | |||||
| Male | 32 | 5 | 2 | 4 | 5 | |
| Female | 11 | 4 | 3 | 3 | 3 | |
| Underlying hypertension: | 0.428 | |||||
| Yes | 12 | 3 | 0 | 3 | 1 | |
| No | 31 | 6 | 5 | 4 | 7 | |
| Diabetes mellitus: | 0.274 | |||||
| Yes | 3 | 1 | 0 | 2 | 0 | |
| No | 40 | 8 | 5 | 5 | 8 | |
| Sepsis: | 0.096 | |||||
| Yes | 16 | 5 | 5 | 4 | 4 | |
| No | 27 | 4 | 0 | 3 | 4 | |
| Post HSCT: | 0.347 | |||||
| Yes | 8 | 0 | 0 | 0 | 1 | |
| No | 35 | 9 | 5 | 7 | 7 | |
| Disease status: | 0.409 | |||||
| Remission | 6 | 2 | 0 | 0 | 0 | |
| Active | 37 | 7 | 5 | 7 | 8 | |
| CNS involvement: | <0.001 | |||||
| Yes | 0 | 0 | 0 | 5 | 1 | |
| No | 43 | 9 | 5 | 2 | 7 | |
| Leukocyte count: | 0.642 | |||||
| ≥100,000 cells/μl | 9 | 2 | 0 | 1 | 0 | |
| <100,000 cells/μl | 34 | 7 | 5 | 6 | 8 | |
| Platelet count: | 0.560 | |||||
| ≥20,000 cells/μl | 27 | 6 | 3 | 6 | 4 | |
| <20,000 cells/μl | 16 | 3 | 2 | 1 | 4 | |
| Prothrombin time: | 0.493 | |||||
| INR ≥1.5 | 10 | 2 | 1 | 1 | 1 | |
| INR <1.5 | 32 | 7 | 4 | 6 | 7 | |
| Location: | ||||||
| Cerebral cortex | 37 | 7 | 5 | 4 | 5 | 0.326 |
| Basal ganglia | 9 | 1 | 1 | 1 | 1 | 0.941 |
| Brainstem | 4 | 0 | 0 | 1 | 0 | 0.628 |
| Cerebellum | 4 | 2 | 0 | 1 | 3 | 0.213 |
| Multiple | 20 | 5 | 0 | 3 | 5 | 0.240 |
| Type: | ||||||
| Intraparenchymal hemorrhage | 35 | 7 | 5 | 4 | 5 | 0.336 |
| Subarachnoid hemorrhage | 8 | 2 | 2 | 0 | 3 | 0.349 |
| Subdural hemorrhage | 11 | 2 | 1 | 4 | 4 | 0.307 |
| Epidural hemorrhage | 1 | 0 | 0 | 0 | 2 | 0.041 |
| Intraventricular hemorrhage | 10 | 4 | 1 | 3 | 2 | 0.618 |
ALL = acute lymphoblastic leukemia; AML = acute myeloid leukemia; APL = acute promyelocytic leukemia; CNS = central nervous system; HSCT = hematopoietic stem cell transplantation; INR = international normalized ratio.