Table 1.
Baseline demographic and clinic characteristics of 373 HIV-infected patients undergoing tuberculin skin test, QuantiFERON-TB Gold and T-SPOT-TB testing, stratified according to past or current tuberculosis (TB) and previous positive tuberculin skin test (TST)
| All patients (n = 373) | Patients with past or current TB (n = 56) | Patients with positive TST treated (n = 15) | Patients with no past or current TB nor positive TST (n = 302) | P value* | |
|---|---|---|---|---|---|
|
Demography |
|
|
|
|
|
| Median age, years (range) |
44 (15-85) |
45 (21-74) |
42 (27-50) |
44 (15-85) |
NS |
| Sex, male |
287 (76.9) |
44 (78.6) |
14 (93.3) |
229 (75.8) |
NS |
| Origin from a country with high prevalence of TB |
28 (7.5) |
7 (12.5) |
1 (6.7) |
20 (6.7) |
NS |
|
HIV-related factors |
|
|
|
|
|
| Prior AIDS defining illness |
144 (38.6) |
50 (89.3) |
4 (26.7) |
92 (30.5) |
<0.001 |
| Median CD4 cell count, cells/μl (range) |
470 (10-1760) |
350 |
442 (120-1200) |
500 (10-1760) |
0.02 |
| |
|
(10-1550) |
|
|
|
| CD4 cell count < 200/μl |
62 (16.6) |
20 (35.7) |
3 (20) |
39 (12.9) |
<0.001 |
| CD4 cell count < 350/μl |
135 (36.2) |
28 (50) |
9 (60) |
101 (33.4) |
0.03 |
| CD4 cell count < 500/μl |
198 (53.1) |
35 (62.5) |
10 (66.7) |
153 (50.7) |
0.07 |
| Median nadir CD4 cell count, cells/μl (range) |
150 (5-1650) |
70 (5-1220) |
240 (42-500) |
180 (5-1650) |
<0.001 |
| Median HIV-1 ARN viral load, copies/ml (range) |
<50 (0-1 x 106) |
115 (0-1 x 106) |
<50 (0-85486) |
<50 (0-1 x 106) |
NS |
| HIV-1 RNA viral load < 50 copies/ml |
218 (58.4) |
35 (49.3) |
11 (74) |
183 (60.6) |
NS |
| ART-naïve |
95 (25.5) |
24 (42.8) |
13 (86.7) |
77 (25.5) |
NS |
| Median time (years) since 1st HIV-positive test (range) |
10 (0-27) |
12 (0.1-22) |
12 (3-24) |
10 (0.1-27) |
0.001 |
| BCG vaccine |
58 (15.8) |
13 (23.2) |
5 (33.3) |
40 (13.9) |
0.02 |
|
Risk factors for TB infection |
|
|
|
|
|
| Contact with patients with TB |
144 (38.7) |
40 (71.4) |
11 (17.3) |
93 (30.9) |
<0.001 |
| History of injection drug use |
187 (50.1) |
35 (62.5) |
14 (93.3) |
138 (45.7) |
0.001 |
| History of prior prison stay |
102 (27.3) |
29 (51.8) |
13 (86.7) |
60 (19.9) |
<0.001 |
| Lived in a shelter or homeless |
97 (26.0) |
22 (39.2) |
6 (40) |
66 (21.9) |
<0.001 |
| Diabetes mellitus |
16 (4.3) |
1 (1.1) |
1 (6.7) |
14 (4.6) |
NS |
| Others |
|
|
|
|
|
| Hepatitis C virus co-infection | 167 (45.1) | 33 (58.9) | 14 (93.3) | 120 (40.0) | <0.001 |
NOTE. Data are no (%) of patients unless otherwise indicated; ART, antiretroviral therapy; BCG, Bacille Calmette-Guérin; * p-value compared the patients with past or current TB and previous positive TST with patients with no past or current TB nor positive TST.