Table 1.
Haemodynamics and structure from baseline, acute, and chronic left bundle branch block simulations and experiments1,15
| Baseline |
Acute LBBB (2 weeks) |
Chronic LBBB (16 weeks) |
||||
|---|---|---|---|---|---|---|
| Simulation | Experiment | Simulation | Experiment | Simulation | Experiment | |
| Heart rate (b.p.m.) | 80 | 101 ± 171 | 80 | 121 ± 471 | 80 | 88 ± 301 |
| 0% | +20% | 0% | −27% | |||
| LV dP/dtmax (mmHg/s) | 2167 | 1803 ± 9091 | 2017 | 1313 ± 4461 | 1964 | 1552 ± 5801 |
| −7% | −35% | −9% | −23% | |||
| LVPmax (mmHg) | 112 | 105 ± 415 | 105 | 100 ± 515 | 109a | 111 ± 4a15 |
| −6% | −5% | +4% | +6% | |||
| LVEDP (mmHg) | 6.7 | 8 ± 61 | 5.9 | 6 ± 71 | 5.8 | 8 ± 51 |
| −12% | −25% | −28% | 0% | |||
| Cardiac output (L/min) | 1.8 | 3.3 ± 1.11 | 1.7 | 2.0 ± 0.9*1 | 1.8 | 3.2 ± 1.31 |
| −6% | −39% | 0% | −3% | |||
| LVEDV (mL) | 46.9 | 104 ± 311 | 49.6 | 110 ± 361 | 57.8 | 135 ± 53*1 |
| +6% | +6% | +23% | +30% | |||
| LVEF (%) | 48 | 43 ± 41 | 42 | 37 ± 8*1 | 38 | 33 ± 6*1 |
| −13% | −14% | −21% | −23% | |||
| LV wall mass (g) | 98 | 126 ± 311 | 101 | 135 ± 371 | 118 | 145 ± 30*1 |
| +3% | +7% | +20% | +15% | |||
Values from experiments are mean ± standard deviation. Per cent changes are with respect to baseline.
LV, left ventricular; dP/dtmax, maximal rate of pressure rise; EDP, end-diastolic pressure; EDV, end-diastolic volume; EF, ejection fraction; Pmax, peak cavity pressure.
aChronic LBBB at 8 weeks.
*P < 0.05 compared with baseline.