Figure 3.

Liver of Long-Evans cinnamon rats is significantly affected by high copper regimen. Hematoxylin and eosin staining of liver. Livers were obtained from Long-Evans cinnamon rats that received high copper at an early or late time point (A, B) or after a reduced copper diet (C: late regimen). As a control, liver of Long-Evans agouti rat is depicted (D). Note highly irregular architecture of liver parenchyma, polyploidy, enlarged nuclei and inflammation (A, B) as compared to C and D. Liver histology of other groups was normal. One representative staining (40× magnification) of female rats is shown.