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. 2012 Oct 23;22(20):1957–1961. doi: 10.1016/j.cub.2012.08.025

Figure 3.

Figure 3

ΔPDZ-Prx Mice Recover Normal Peripheral Nerve Conduction Velocities and Behavior after Retarded Schwann Cell Growth during Development

(A) Internodal lengths of teased quadriceps fibers from control and ΔPDZ-Prx nerves at 3, 6, and 16 weeks (mean values ± SEM, n ≥ 5 per group; ∗∗∗p < 0.001).

(B) Nerve conduction velocities in control and ΔPDZ-Prx quadriceps nerves at 3, 6, and 16 weeks (mean values ± SEM, n ≥ 5 per group; ∗∗∗p < 0.0001). Conduction velocities at 16 weeks in ΔPDZ-Prx nerves were not significantly different from controls.

(C) Motor coordination was evaluated in control and ΔPDZ-Prx mice at 3 and 16 weeks using the rotarod test. At 24 rpm, there was no difference in rotarod performance between control and ΔPDZ-Prx mice at both ages. However, under more demanding conditions at 32 rpm, ΔPDZ-Prx mice performed significantly worse (mean values ± SEM, n ≥ 12 per group; n.s., not significant, ∗p < 0.05). Motor coordination of 16-week-old ΔPDZ-Prx mice did not differ significantly from control values at 32 rpm.