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. 2012 Oct 29;3:322. doi: 10.3389/fimmu.2012.00322

Figure 1.

Figure 1

The IL-1 receptor (ILRs) and Toll like receptor (TLRs) superfamily. Ligands, receptors, adaptors, and extracellular and intracellular negative regulators are shown. The ILRs family includes the receptors (IL-1RI, IL-18R, T1/ST2, IL-1Rrp2) and the accessory proteins (IL-1RAcP) for IL-1, IL-18, IL-33, and other IL-1 family members (IL-36α, IL-36β, and IL-36γ). IL-1Ra, soluble IL-1RI, IL-36Ra, IL-37, IL-18 binding protein (IL-18BP), IL-1RII, and TIR8/SIGIRR are negative regulators acting at different levels, as receptor antagonists, decoy receptors, scavengers, or dominant negative. TIR8/SIGIRR, TIGIRR-1, and TIGIRR-2 are still orphan receptors. Microbial moieties (LPS, Poly I:C, CpG, Flagellin, and others) and necrotic cell-derived danger signals are the ligands for TLRs.