Table 1.
Regulation of TIR8/SIGIRR expression.
| Stimuli | Organism | Cell type | mRNA/protein | Reference |
|---|---|---|---|---|
| UPREGULATION | ||||
| Th2-polarization | Mouse | T lymphocytes | Protein | Bulek et al. (2009) |
| Vasoactive intestinal peptide | Mouse | Macrophages and langerhans cells | mRNA | Jiang et al. (2012) |
| LPS | Mouse | Payer’s patch DCs | mRNA | Davies et al. (2010) |
| DOWNREGULATION | ||||
| LPS | Mouse and human | Epithelial cells, DC, monocytes, polymorphonuclear granulocytes | mRNA, protein | Polentarutti et al. (2003), Wald et al. (2003), Huang et al. (2006), Garlanda et al. (2004), Kadota et al. (2010) |
| Flagellin, bacterial infection | Mouse and human | Intestinal epithelial cells | Protein | Khan et al. (2010) |
| Psoriatic arthritis | Human | Peripheral blood leukocytes | mRNA | Batliwalla et al. (2005) |
| Necrotizing enterocolitis | Human | Fetal enterocytes | mRNA | Nanthakumar et al. (2011) |
| Asymptomatic bacteriuria | Human | Neutrophil polymorphonuclear granulocytes | Protein | Ragnarsdottir et al. (2007) |
| P. aeruginosa acute lung infection | Mouse | Respiratory epithelium, polymorphonuclear granulocytes | mRNA | Veliz Rodriguez et al. (2012) |
| Toxoplasma gondii | Mouse | Intestinal epithelial cells | mRNA | Gopal et al. (2008) |