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LXR activation suppresses diabetes-induced renal inflammation and macrophage infiltration. qRT-PCR analysis of the expressions of two macrophage markers, CD14 and CD11c, reveals that T0901317 inhibits diabetes-induced macrophage infiltration into the kidney. Similarly, T0901317 suppresses the MCP-1, TNF-α, and TGF-β mRNA levels in the kidney. The mRNA levels were normalized by the GAPDH mRNA level. Data are means ± SEM. *P<0.05.
