Table 1.
Metabolic data at 8 weeks after the induction of diabetes
| Control (n=8) | DM (n=8) | DM+T0901317 (n=8) | |
|---|---|---|---|
| Systolic BP (mmHg) | 102.7±6.7 | 115.9±3.8 | 113.2±2.7 |
| HbA1c (%) | 4.25±0.05 | 9.03±0.46a | 9.14±0.46a |
| Body weight (g) | 26.57±0.35 | 18.66±1.23a | 20.23±0.79a |
| Kidney weight (mg) | 273.7±7.3 | 311.3±20.0 | 278.6±10.1 |
| Relative kidney weight (mg/g body weight) | 11.23±0.46 | 17.22±1.54a | 13.86±0.52b |
| Triglycerides (mg/dl) | 25.3±2.1 | 43.0±14.7 | 42.9±8.1 |
| UAE (μg/24 h) | 9.3±1.2 | 82.8±11.7a | 52.9±7.5a,b |
Data are means ± SEM. Control, nondiabetic control mice; DM, untreated diabetic mice; DM+T0901317, T0901317-treated diabetic mice; HbA1c, hemoglobin A1c; UAE, urinary albumin excretion.
a
P<0.01 versus the control group.
b
P<0.01 versus the DM group.