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. 2012 Nov;23(11):1847–1856. doi: 10.1681/ASN.2012010078

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Copyright © 2012 by the American Society of Nephrology

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Figure 4. — The glomerular permeability of AGT and albumin is higher in glomerulosclerosis and increases with aging. Quantitative imaging of the glomerular permeability of (A) Atto565-hAGT and (B) Atto565-albumin in vivo in MWF rats, a model of glomerulosclerosis. In addition to the glomerular (G) capillary plasma, intense Atto565 fluorescence (red) was visible in cells of the proximal tubule (PT), indicating tubular uptake. Autofluorescence is shown in green. (C) Age-dependent changes in GSC of Atto565-hAGT (solid circles) or Atto565-albumin (open circles). GSCs were analyzed from at least eight glomeruli in each rat. GSC of Atto565-hAGT in young rats (42 days old; 0.0010±0.0003) tended to be lower than GSC of Atto565-albumin at similar age (40 days old; 0.0018±0.0004). This trend became more apparent with aging (Atto565-hAGT GSC=0.0014±0.0002 at 130 days old versus Atto565-albumin GSC=0.0058±0.0015 at 130 days old).