A, Clonal growth and population doubling time of hCSCs dividing by asymmetric (old DNA, red) and symmetric (new DNA, blue) chromatid segregation, respectively. B, Rate of apoptosis and senescence of in hCSC classes; mean±SD. *P<0.05 vs. New DNA. C, Distribution of telomere length in hCSC subsets; in hearts 46–83 years (y) old, telomere length of hCSCs carrying the old DNA is shifted towards higher values. Telomere length decreases with age only in hCSCs carrying the new DNA. D, Telomerase activity in hCSC subsets measured by qPCR; individual values are shown together with mean±SD.