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Minimum bactericidal concentrations and the corresponding NO doses required from NO-releasing PPI-SO dendrimers to elicit a 5-log reduction in bacterial viability (≥99.999% killing)
| Species | 5a (PPI-8-SO-NO)
|
6a (PPI-64-SO-NO)
|
||||
|---|---|---|---|---|---|---|
| MBC (μM) | MBC (μg·mL−1) | Bactericidal NO Dose (μmol·L−1) | MBC (μM) | MBC (μg·mL−1) | Bactericidal NO Dose (μmol·L−1) | |
| P. aeruginosa | 10 | 17.1 | 20.2 | 1 | 14.8 | 15.2 |
| S. aureus | 10 | 17.1 | 20.2 | 0.5 | 7.4 | 7.6 |
| MRSA | 10 | 17.1 | 20.2 | 0.5 | 7.4 | 7.6 |
