Table 3.

Risk of Coronary Heart Disease Associated with Increment in Levels of Total Cholesterol, LDL Cholesterol, HDL Cholesterol, and 27-OH Cholesterol

Biomarker	Odds Ratio per 10% Increment in Biomarker Level (95% Confidence Interval)
	Model 1*	Model 2†	Model 3‡	Model 4§	Model 5**	Model 6††	Model 7‡‡
Total cholesterol	1.12 (1.03, 1.21)	1.19 (1.09, 1.31)	1.18 (1.07, 1.29)
LDL-cholesterol	1.11 (1.05, 1.17)	1.15 (1.08, 1.23)	1.14 (1.07, 1.22)
HDL-cholesterol	0.87 (0.82, 0.91)	0.93 (0.87, 0.99)	0.92 (0.87, 0.99)
27-OH cholesterol	1.02 (0.97, 1.08)	1.07 (1.00, 1.14)		1.08 (1.01, 1.15)	1.04 (0.97, 1.11)	1.04 (0.97, 1.11)	1.04 (0.98, 1.11)

^*Estimated odds ratio for CHD during trial compared with controls for a 10% increment in log-transformed biomarker value from a logistic regression model adjusted for treatment assignment (CEE, CEE placebo, CEE+MPA, CEE+MPA placebo) and age

^†Adjusted for treatment assignment, age,^ race/ethnicity, diabetes mellitus, smoking status, history of cardiovascular disease,^ alcohol consumption, systolic blood pressure, diastolic blood pressure, body mass index, waist circumference, C-reactive protein, glucose, history of high blood cholesterol, LVH, use of antihypertensive medication, aspirin, or statins.

^‡Adjusted for the aforementioned covariates included in model 2, and 27-OH cholesterol

^§Adjusted for the aforementioned covariates included in model 2, and HDL-cholesterol

^**Adjusted for the aforementioned covariates included in model 2, and LDL-cholesterol

^††Adjusted for the aforementioned covariates included in model 2, and total cholesterol

^‡‡Adjusted for the aforementioned covariates included in model 2, and HDL-cholesterol and LDL-cholesterol.

^{^}Matching variables.