Fig. 3.

Mutant p53 as the hub of oncogenic pathways in breast cancer. The activity of mutant p53 is regulated through upstream signal transducers as well as regulators of transcription, stability and structure. Its biological effects are mediated by direct transcriptional activity and through association with downstream protein effectors. These mechanisms are interconnected (small arrows), especially downstream of mutant p53, as most proteins bound directly are transcription regulators. The figure includes only the factors/processes that were found to affect the tumorigenic features of breast cancer models or patients and target genes found to be directly regulated by mutant p53. *PTMs—Posttranslational Modifications may be affected by upstream factors and may influence downstream effects of mutant p53. †TopBP1 is implicated as a coordinator protein of mutant p53 GOF exerted via NF-Y, p63 and p73.