Table 4. R2-Pyrazole Modificationsd.
Results are mean values for samples run in triplicate.
MLM/HLM: Percentage of parent compound metabolized after a 30 min incubation.
Calculated log P.(46)
For both Aurora-A IC50 and SW620 human colon cancer cell GI50 determinations, the results are mean values of two independent determinations or mean (±SD) for n > 2 unless specified otherwise.