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. 2012 Oct 8;55(20):8721–8734. doi: 10.1021/jm300952s

Table 4. R2-Pyrazole Modificationsd.

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a

Results are mean values for samples run in triplicate.

b

MLM/HLM: Percentage of parent compound metabolized after a 30 min incubation.

c

Calculated log P.(46)

d

For both Aurora-A IC50 and SW620 human colon cancer cell GI50 determinations, the results are mean values of two independent determinations or mean (±SD) for n > 2 unless specified otherwise.